ID-CLD Particle Size & Count

Image Analysis Derived Chord Length Distribution

Overview 

Blaze Image Derived Chord Length Distributions (ID-CLD) provide data and trends familiar to thousands of process development experts but with substantially improved linearity, precision, accuracy and repeatability over changing dispersed phase properties (solids concentration/size/shape/surface/translucent-opacity).

These improvements lead to better and faster process understanding and hence shorter development times and often better and more robust processes.

 

What has Blaze done to achieve this enabling capability?
 

  • Blaze is not impacted by changes in particle velocity. What changes particle velocity? Changes in continuous phase viscosity, dispersed phase solids concentration, particle size, shape and distribution, and of course, mixing speed or flow rate.

  • Blaze limits the depth of measurement substantially improving measurement linearity over changing dispersed phase concentration and/or particle size changes. Both dispersed phase concentration and particle size changes impact depth of field. By limiting this depth of field, the measurement 'sample' volume (i.e. sample size) is kept more consistent over process changes, substantially improving measurement linearity and precision. 

    • An additional benefit of the Blaze limited depth of field measurement zone is that it enables operation at significantly higher dispersed phase concentrations and/or smaller sizes while retaining the ability to measure change with sensitivity.

Note: Blaze still provides substantially higher detection and sensitivity to change at ultra low dispersed phase concentration due to its image rate and processing speed.

  • Blaze detects dark grays that other tools see as black, and light grays that other tools see as white. This extended range of 'shades of gray' enables earlier detection, greater operational range from low to high dispersed phase concentration, better edge detection for both CLD (1d) and 2d image processing which all lead to greater precision across a wide range of changing process conditions.

 

  • ​Blaze 'scanning beam' (line of pixels) ranges from 130nm to 500nm depending on the Blaze model. For comparative tools, Blaze has an order of magnitude smaller (higher resolution) detection required for both measurement accuracy and precision. Where other CLD tools 'guesstimate' <10um, Blaze truly measures down to 1.5um. Note the BlazeMeso measures CLD down to 400nm and, depending on optical properties, can detect the existence of particles substantially smaller than 400nm.  See Blaze Tool Detection Ranges here.

 

  • The amazing value of always having Microscopy and HDR Turbidity cannot be overstated. These orthogonal tools help remove the guesswork, vastly improve ease of use, and most importantly enable a deeper process understanding. Once againm leading to faster development times and often better and more robust processes. 

 

Every day more CRO's and CDMO's turn to BlazePAT for deeper process understanding and development speed. See our current collaborations here.

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