Nano < Meso < Micro < Milli. Physical, Chemical, & Biological.
Multiple Best-in-Class PAT in a Single Probe,
Simultaneous Acquisition.
Choice of Technologies in a Single Probe. Eliminate the guesswork, measure the change.
Single Probe - Multiple Measurement Technologies
Small Molecule
-
Milling
-
Crystallization
-
Formulation
-
Dissolution Studies
-
Blend Uniformity
-
Encapsulation
Large Molecule
-
Bioreactor-Cells
-
Clarification
-
Foreign Matter
-
Protein
-
Agglomeration
Blaze high contrast, high resolution, & high dynamic range in-process microscopy enables a next generation understanding of single & multiple dispersed phase particle systems at the highest solids, smallest particle sizes, and widest range of particle composition types.
Blaze Image Derived Chord Length Distributions (ID-CLD) provide data and trends familiar to thousands of process development experts but with substantially improved linearity, precision, accuracy and repeatability over changing dispersed phase properties (solids concentration/size/shape/surface/translucent-opacity). These improvements lead to better and faster process understanding and hence shorter development times and often better and more robust processes.
Improves signal from suspended solids. Depending on the conditions, the Blaze can substantially increase the solids signal captured dynamically in process. This enables users to better identify small volumes and/or track small changes in polymorphs, solvates, hydrates, & particulate impurities; as well as better differentiate particle types in multiple component systems. Blaze Raman pairs with most spectrometers.
Blaze Raman
Standard Raman
Extends the measurable range between the minimum detectable value of back-scattered light (no to low dispersed phase i.e. earlier cloud point detection vs traditional tools) to the largest amount of back-scattered light (highest dispersed phase concentration with the smallest particle sizes -- hence the most scattering surface area -- i.e. detecting attrition or size reduction at the highest solids loading and smallest sizes).
Blaze uses OPC to transfer statistics between the Blaze and Process Control Software. Real-time reactor & other PAT inputs (i.e. Tr, Dosing, pH, Raman,…) can be fed to the Blaze UI for real-time trend & microscopy compare as well as saving for future evaluation. Blaze stats can be sent to control platforms such as Perceptive Engineering, Systag FlexyPAT, & iControl for real-time control action &/or data logging.
*Copyright and technology for FBRM® sold by Lasentec to MettlerToledo
iControl® property of Mettler Toledo
Blaze Patented Technology
The Blaze patented single optical path technology allows multiple analytical technologies to simultaneously utilize the same optical path. This creates both an enabling combination of measurement tools while reducing the cost of ownership through reduced capital costs, installation costs, maintenance costs, and utilization costs. Combined with other Blaze exclusive IP, Blaze probes provide best-in-class process analytical technology.
Lab
Tools created for the lab environment with a choice of multiple technologies in a single probe. Click the button below to continue to Lab Tools.
12/14/19mm x 276mm Wetted Length
Pilot - Production
Tools created for the production environment with a choice of multiple technologies in a single probe. Click the button below to continue to Pilot Tools.
630mm Wetted Length