Blaze I Applications I Overview
Note: 3840 x 2160 computer monitor resolution is required to see the full image resolution of Blaze Microscopy. This resolution is not typically supported on standard desktop computers.
Blaze proprietary design enables particle system characterization at ultra low solids/dispersed phase concentration to the industries best high solids/dispersed phase concentration.
Blaze systems are used for a wide range of application from submicron and subvisible detection to oversize or foreign mater detection at the industries best high solids concentration.
Blaze can utilize particle size, count in isolated size regions, shape, surface, or other physical and chemical attributes to track the rate and degree of change to particles and particle structures as they naturally exist in process.
Change in chemical composition can be tracked through the use of physical properties (shape, surface etc.), optional PF Raman integration, or a combined use of physical/Raman characterization.
Detection: The first examples below are representative of detecting submicron & larger subvisible particles at extremely low particle count, i.e., foreign mater, nucleation, oiling out, protein agglomerates, etc.
Nucleation: Directly below is a slide show from the precipitation of a poorly water soluble API. First detection, confirmed by an offline tool, was approximate 200nm. Blaze400 pixels are 0.2µm square. These particles grew to a distribution near 2µm.
Same Crystal System, left during growth, right during dissolution.
Crystallization, pre-Seed: Blaze interrogates 58 images per second, 3,480 images per minute and can select and count only those images with content. The screen shot below is representative of the 10s of images selected from 10s of thousands of images. Fibers, dust, and in some cases contaminate crystals. How do this impact your process? See the images following:
Crystallization, pre-Seed: It has been common for Blaze to observe crystals forming on foreign matter prior to seeding.
Crystallization, pre-Seed: In some cases, it appears that the crystallization on foreign matter pre-seed forms a seed bed significantly impacting the process.
Crystallization, Seed: Foreign matter not detected pre-seed identified along with the seed. The assumption is that the foreign matter was brought into the process with the seed. In some cases, secondary crystalline substances came in with the seed.
Crystallization, secondary nucleation on surface
10.4µm polystyrene beads